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　　該小組的研究發(fā)現黑色素瘤和非黑色素瘤性病變有22個(gè)基因甲基化水平顯著(zhù)不同，以及有12個(gè)點(diǎn)可以高度預測惡性黑色素瘤。對于托馬斯來(lái)說(shuō)，團隊的另一個(gè)目標是建立一個(gè)黑色素瘤腫瘤細胞DNA的脫落進(jìn)入血液試驗，并可以作為測量疾病DNA甲基化的依據。
　　“如果這測試可以發(fā)展起來(lái)的,它將開(kāi)啟早期診斷和治療復發(fā)腫瘤的大門(mén)，腫瘤剛發(fā)生時(shí)更容易治療，這也給我們提供了另一種方式，以監測患者對治療的反應，并幫助我們更好地優(yōu)化處理每一個(gè)病人，“托馬斯說(shuō)。
　　這項研究是由美國國家癌癥研究所和一個(gè)UNC萊恩伯格試點(diǎn)格蘭特贊助。
　　愛(ài)愛(ài)醫推薦原文閱讀：
　　A new study shows that a test of biomarkers for DNA methylation is technically feasible and could aid in earlier, more precise diagnosis of melanoma.
　　In a paper that recently appeared online in the journal Pigment Cell & Melanoma Research, a team of UNC researchers tested whether DNA methylation profiling could be accomplished on melanoma and mole tissues that had been preserved in fixatives for typical pathology examination after biopsy. They found that results on tissues prepared in this way were reliable and DNA methylation distinguished malignant melanomas from non-malignant moles.